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A 3D printing-based device to greatly enhance the accuracy
and speed of administration into the cerebrospinal fluid in the
Bottom panel with magnet attached
Method of Use
Place the mouse on the injector
Align the tip of the eye of
the mouse with the indicator
Injection with a needle through
the insertion hole
(For additional experiments)
Repeat numbers 1 to 3 after
replacing the module
I.C.V injection placements.
Compared to no holder, use of the HFH significantly increased the probability
that trypan blue was administered into the lateral ventricle.
In vivo fluorescence imaging using cy5.5. Cy5.5 was applied at 20uL in
phosphate- bufferd saline cia asingle intracerebroventricular(i.c.v.)
injection into the brains of healthy mice. A representative image of a
mouse head with cy5.5 visualized as a hotspot using fluorescence imaging.
B Representative image of a mouse brain section with cy 5.5 visualized
as a hotspot using fluorescence imaging.
Significantly improves convenience of the experiment, productivity, and
economy feasibility more than other similar products.
Maximum number of experiments
performed per day
30 - 60 minutes
5 - 8 animals
250 - 300 animals
Improvement in the convenience of the researcher
Increased experiment productivity
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